| Autor: |
Timothy J. Hibberd, Marcello Costa, David J. Smolilo, Lauren J. Keightley, Simon J. Brookes, Phil G. Dinning, Nick J. Spencer |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
American journal of physiology. Gastrointestinal and liver physiology. 323(2) |
| ISSN: |
1522-1547 |
| Popis: |
Colonic motor complexes (CMCs) are a major neurogenic activity in guineapig distal colon. The identity of the enteric neurons that initiate this activity is not established. Specialized intrinsic primary afferent neurons (IPANs) are a major candidate. We aimed to test this hypothesis. To do this, segments of guineapig distal colon were suspended vertically in heated organ baths and propulsive forces acting on a pellet inside the lumen were recorded by isometric force transducer while pharmacological agents were applied to affect IPAN function. In the absence of drugs, CMCs acted periodically on the pellet, generating peak propulsive forces of 12.7 ± 5 g at 0.56 ± 0.22 cpm, lasting 49 ± 17 s (215 preparations |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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