Physiology and Pathophysiology of Itch
| Autor: | Ferda Cevikbas, Ethan A. Lerner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Physiology Disease Review 03 medical and health sciences 0302 clinical medicine immune system diseases Physiology (medical) Sensation parasitic diseases medicine otorhinolaryngologic diseases Animals Humans Chronic itch skin and connective tissue diseases Molecular Biology Skin Neurons business.industry Pruritus General Medicine eye diseases 030104 developmental biology Spinal Cord Itching medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Physiol Rev |
| Popis: | Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly understood and appreciated. The pathophysiological consequences of itch impact quality of life as much as pain. These dynamics have led to increasingly deep dives into the mechanisms that underlie and contribute to the sensation of itch. When the prior review on the physiology of itching was published in this journal in 1941, itch was a black box of interest to a small number of neuroscientists and dermatologists. Itch is now appreciated as a complex and colorful Rubik’s cube. Acute and chronic itch are being carefully scratched apart and reassembled by puzzle solvers across the biomedical spectrum. New mediators are being identified. Mechanisms blur boundaries of the circuitry that blend neuroscience and immunology. Measures involve psychophysics and behavioral psychology. The efforts associated with these approaches are positively impacting the care of itchy patients. There is now the potential to markedly alleviate chronic itch, a condition that does not end life, but often ruins it. We review the itch field and provide a current understanding of the pathophysiology of itch. Itch is a disease, not only a symptom of disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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