Nephrotoxicity of Kalach 360 SL: biochemical and histopathological findings

Autor:	Latifa Hamdaoui, Manel Naifar, Mariem Ben Salem, Fatma Makni-Ayadi, Amel Chtourou, Zouheir Sahnoun, Tarek Rebai, Massara Mzid
Rok vydání:	2016
Předmět:	0301 basic medicine medicine.medical_specialty Health Toxicology and Mutagenesis Urinary system Glycine Renal function Urine 010501 environmental sciences Toxicology Kidney Kidney Function Tests 01 natural sciences Antioxidants Nephrotoxicity Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar 0105 earth and related environmental sciences Dose-Response Relationship Drug Body Weight Organ Size Oxidative Stress 030104 developmental biology Endocrinology chemistry Urine osmolality Urea Uric acid Environmental Pollutants Female Lipid Peroxidation Biomarkers
Zdroj:	Toxicology mechanisms and methods. 26(9)
ISSN:	1537-6524
Popis:	Kalach 360 SL (KL) is a commercial herbicide which contains 360 g/l of glyphosate used in both agricultural and urban areas throughout the world including Tunisia. We aimed to evaluate the effects of KL on rats' renal system. Female Wistar rats were divided into three groups: group 1 (n = 6) received a standard diet and served as control, groups 2 and 3 (n = 12 each) received 0.07 ml (D1: 126 mg/kg), and 0.175 ml (D2: 315 mg/kg) of KL, respectively, for 60 d. The chronic exposure to KL induced a significant increase in plasma creatinine, urea, and uric acid levels. Creatinine clearance decreased in KL-treated groups, compared with controls. Several urine parameters, such as urine-specific gravity and urine osmolality, significantly decreased, while dieresis and urinary Na/K + ratio increased in KL-treated groups. These findings suggested a distal tubular damage caused by tubular necrosis. Moreover, the chronic exposure to KL induced an increase in lipid peroxidation (LPO) and a decrease in antioxidant status, enzymatic activities (superoxide dismutase and catalase) and non-enzymatic levels (vitamin C), which led to an oxidative stress. Histopathological studies showed a peritubular inflammatory reaction, nephrose, fragmented glomeruli, necrotic epithelial cells, and tubular dilatation. These results could have significant health implications for animal and human populations. Further data are necessary to investigate the potential consequences of chronic dose exposure during life.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4330256231d5141f6c000d6720d25f18 https://pubmed.ncbi.nlm.nih.gov/27580939 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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