Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora
| Autor: | Cecilia Prata, Alessandra Locatelli, Rogers Alberto Nahui Palomino, Rita Morigi, Mirella Rambaldi, Beatrice Vitali, Alessandra Graziadio, Alberto Leoni |
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| Přispěvatelé: | Morigi, Rita, Vitali, Beatrice, Prata, Cecilia, Palomino, Rogers A. A, Graziadio, Alessandra, Locatelli, Alessandra, Rambaldi, Mirella, Leoni, Alberto |
| Rok vydání: | 2017 |
| Předmět: |
1‐b]thiazole
lactobacilli 0301 basic medicine Antifungal Agents Stereochemistry Thiazolidine Urogenital System bifidobacteria Antineoplastic Agents antiproliferative effects 02 engineering and technology Microbial Sensitivity Tests 03 medical and health sciences chemistry.chemical_compound Ampicillin Lactobacillus Drug Discovery medicine Humans Thiazole Imidazo[2 urogenital pathogens biology Chemistry Imidazoles 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification Anti-Bacterial Agents Thiazoles 030104 developmental biology Nitrogen atom Bifidobacterium Econazole 0210 nano-technology Imidazothiazole derivatives Bacteria medicine.drug HeLa Cells |
| Zdroj: | Medicinal chemistry (Shariqah (United Arab Emirates)). 14(3) |
| ISSN: | 1875-6638 |
| Popis: | Background Fused five-membered heterocyclic rings containing bridgehead nitrogen atom are particularly versatile in the field of medicinal chemistry because of their different biological activities. Among them, the imidazo[2,1-b]thiazole is an attractive fused heterocyclic core that has been extensively studied. Objective The aim of the current study was to study the therapeutic applications of imidazo[2,1- b]thiazole derivatives as antimicrobial agents for the treatment of genitourinary infections. Method A traditional synthetic methodology was involved to obtain a small series of imidazothiazole derivatives. Results Herein, we report the antimicrobial activity of the imidazo[2,1-b]thiazole or imidazo[2,1- b]thiazolidine derivatives against selected fungi, Gram-positive and Gram-negative bacteria. Moreover, experiments were carried out to investigate the interference towards the endogenous microbiota. Conclusion The most interesting of the series are the thiocyano derivatives (19, 23) showing a good profile for the treatment of genitourinary infections: a spectrum of activity covering both bacteria and fungi together with a reduced impact versus critical lines of Lactobacillus exerting defense against pathogens. |
| Databáze: | OpenAIRE |
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