Arsenite Acutely Decreases Nitric Oxide Production via the ROS—Protein Phosphatase 1—Endothelial Nitric Oxide Synthase-Thr497Signaling Cascade
| Autor: | Min Sun Sung, Jung Hyun Park, Inho Jo, Jee Young Lee, Hyeon Ju Lee, Jungwon Seo, Ho-Seong Cho, Catherine Jeonghae Byun, Sung-Jin Cho, Du Hyong Cho |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Biology Vascular disease Biochemistry Nitric oxide chemistry.chemical_compound Protein phosphatase 1 Enos Internal medicine Drug Discovery medicine Protein kinase C Arsenite Pharmacology chemistry.chemical_classification Reactive oxygen species biology.organism_classification Molecular biology Endocrinology chemistry Molecular Medicine Phosphorylation Original Article Endothelial nitric oxide synthase Signal transduction |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 1976-9148 2005-4483 |
| DOI: | 10.4062/biomolther.2014.106 |
| Popis: | Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOS-Ser(1179) in bovine sequence), which is associated with increased risk of vascular diseases. Here, we investigated the acute ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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