The Continuum of Acid Stress
| Autor: | Donald E. Wesson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epidemiology 030232 urology & nephrology Reviews 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Stress Physiological Internal medicine medicine Kidney injury Humans Acidosis Acid stress Acid-Base Equilibrium Transplantation Kidney business.industry Chronic metabolic acidosis Metabolic acidosis Plasma bicarbonate medicine.disease Diet Bicarbonates medicine.anatomical_structure Endocrinology Nephrology Chronic Disease Kidney Diseases medicine.symptom business Acids Oxidative stress Glomerular Filtration Rate |
| Zdroj: | Clin J Am Soc Nephrol |
| ISSN: | 1555-905X 1555-9041 |
| Popis: | Acid-related injury from chronic metabolic acidosis is recognized through growing evidence of its deleterious effects, including kidney and other organ injury. Progressive acid accumulation precedes the signature manifestation of chronic metabolic acidosis, decreased plasma bicarbonate concentration. Acid accumulation that is not enough to manifest as metabolic acidosis, known as eubicarbonatemic acidosis, also appears to cause kidney injury, with exacerbated progression of CKD. Chronic engagement of mechanisms to mitigate the acid challenge from Western-type diets also appears to cause kidney injury. Rather than considering chronic metabolic acidosis as the only acid-related condition requiring intervention to reduce kidney injury, this review supports consideration of acid-related injury as a continuum. This “acid stress” continuum has chronic metabolic acidosis at its most extreme end, and high-acid-producing diets at its less extreme, yet detrimental, end. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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