Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
| Autor: | Rajesh Shah, Nils Hovdenak, James Versalovic, Reka Szigeti, Emily B. Hollister, R. Alan Harris, Rune Rose Tronstad, Richard Kellermayer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Male 0301 basic medicine Sodium-Hydrogen Exchangers Adolescent Article Subject Colorectal cancer Immunology Disease Biology Epigenesis Genetic 03 medical and health sciences Crohn Disease RNA Ribosomal 16S medicine Humans Immunology and Allergy Epigenetics Microbiome Intestinal Mucosa Child Gene Sodium-Hydrogen Exchanger 3 Microbiota Proteins General Medicine Epigenome DNA Methylation medicine.disease Ulcerative colitis Healthy Volunteers digestive system diseases 3. Good health 030104 developmental biology Child Preschool DNA methylation Colitis Ulcerative CpG Islands Female lcsh:RC581-607 Research Article |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2016 (2016) |
| ISSN: | 2314-8861 |
| DOI: | 10.1155/2016/9170162 |
| Popis: | Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial16S rRNAgene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|