Cocaine selectively increases proliferation in the adult murine hippocampus
| Autor: | Steven A. Lloyd, Frank S. Corotto, Richard J. Smeyne, Zachary R. Balest |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Neurogenesis Hippocampus Subventricular zone Biology Hippocampal formation Article Subgranular zone Cocaine-Related Disorders Mice Cocaine Dopamine Uptake Inhibitors Dopamine Internal medicine medicine Animals Cell Proliferation Neuronal Plasticity General Neuroscience Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Endocrinology Forebrain Indirect agonist Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 485:112-116 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2010.08.080 |
| Popis: | Cocaine abuse continues to be a significant problem in the USA and elsewhere. Cocaine is an indirect agonist for dopamine, norepinephrine and serotonin with numerous potential downstream effects, including processes and signals associated with adult neurogenesis. Since drug addiction is associated with brain plasticity, we hypothesized that cocaine exposure would alter cellular proliferation in two adult neurogenic regions (the subventricular and subgranular zones). We used bromodeoxyuridine (BrdU) to track newly generated cells in the brains of adult mice after chronic cocaine or saline exposures. No differences were found in the number or migration patterns of BrdU-labeled cells in the forebrain neurogenic areas. However, cocaine produced a significant increase in the number of hippocampal BrdU-labeled cells. |
| Databáze: | OpenAIRE |
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