Mice lacking neuronal calcium sensor-1 show social and cognitive deficits
| Autor: | Ariel Avila, Kathleen Trought, Albert H.C. Wong, Enoch Ng, Ho Suk Mun, Graham L. Collingridge, Panayiotis Servinis, John Georgiou, John C. Roder, Meggie Hodgson |
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| Rok vydání: | 2020 |
| Předmět: |
Long-Term Potentiation
Neuronal Calcium-Sensor Proteins Social Interaction Hippocampus chemistry.chemical_element Anxiety Calcium Receptors Metabotropic Glutamate Choice Behavior Mice 03 medical and health sciences Behavioral Neuroscience Cognition 0302 clinical medicine Animals Social Behavior Long-term depression CA1 Region Hippocampal Spatial Memory 030304 developmental biology Mice Knockout 0303 health sciences Neuronal Plasticity biology Dentate gyrus Neuropeptides Glutamate receptor Recognition Psychology Long-term potentiation Sensory Gating Frontal Lobe Neuronal calcium sensor-1 chemistry Dentate Gyrus Synaptic plasticity biology.protein Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 381:112420 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2019.112420 |
| Popis: | Neuronal calcium sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal calcium sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and bipolar disorder. However, the role of neuronal calcium sensor-1 in behavioural phenotypes and brain changes relevant to autism spectrum disorder have not been evaluated. We show that neuronal calcium sensor-1 deletion in the mouse leads to a mild deficit in social approach and impaired displaced object recognition without affecting social interactions, behavioural flexibility, spatial reference memory, anxiety-like behaviour, or sensorimotor gating. Morphologically, neuronal calcium sensor-1 deletion leads to increased dendritic arbour complexity in the frontal cortex. At the level of hippocampal synaptic plasticity, neuronal calcium sensor-1 deletion leads to a reduction in long-term potentiation in the dentate gyrus, but not area Cornu Ammonis 1. Metabotropic glutamate receptor-induced long-term depression was unaffected in both dentate and Cornu Ammonis 1. These studies identify roles for neuronal calcium sensor-1 in specific subregions of the brain including a phenotype relevant to neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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