Influence of prostaglandin synthetase inhibitors on the renal effects of histamine
| Autor: | Mary Ann Neel, Ewald E. Selkurt |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Allergy Immunology Indomethacin Prostaglandin Toxicology Renal Circulation Excretion chemistry.chemical_compound Electrolytes Dogs Internal medicine medicine Animals Pharmacology (medical) Cyclooxygenase Inhibitors Receptor Pharmacology biology Chemistry Osmolar Concentration Prostaglandin synthesis medicine.disease Endocrinology Renal blood flow Creatinine biology.protein Vascular Resistance Cyclooxygenase Histamine |
| Zdroj: | Agents and actions. 15(3-4) |
| ISSN: | 0065-4299 |
| Popis: | The increase in renal blood flow and accompanying increase in excretion of electrolytes (e.g., Na+, Ca2+, and other osmolar constitutents) produced by intra-renal arterial infusion of histamine in dogs are reduced by the inhibitors of cyclooxygenase activity, indomethacin and RO 20-5720, given intravenously. This suggests the possibility that histamine might be acting in conjunction with the renal prostanoids, either by stimulating their release by activating prostaglandin synthesis, or by acting at the PG receptor sites in a similar manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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