Decrease of bone formation in adult women with fragility fractures
| Autor: | F. Bottega, Giovanni Luisetto, D. Ziliotto, A. Nardi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Aging
medicine.medical_specialty Time Factors Bone density Bone disease Osteocalcin Osteoporosis Urology General Biochemistry Genetics and Molecular Biology Body Mass Index Bone remodeling Forearm Bone Density Reference Values Internal medicine medicine Humans Bone formation Osteoporosis Postmenopausal Aged Aged 80 and over Bone mineral business.industry Obstetrics and Gynecology Middle Aged Alkaline Phosphatase medicine.disease Postmenopause Menopause Cross-Sectional Studies medicine.anatomical_structure Endocrinology Female business Biomarkers |
| Zdroj: | Maturitas. 28:59-67 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/s0378-5122(97)00046-7 |
| Popis: | To compare bone mineral density (BMD) and some markers of bone metabolism in women with fragility fractures and in normal age-matched subjects.A 100 women with at least one vertebral deformity25%, and 219 age-, BMI- and parity-matched healthy women, were recruited for the study. In all the patients fractures were symptomatic and occurred at least 1 year before densitometric measurement. Forearm bone mineral density (BMD) as well as biochemical assessment of some markers of bone turnover were measured in all the subjects.BMD was significantly lower in the fracture than in the control group (0.326 +/- 0.073 vs. 0.379 +/- 0.079; P0.001). Fractured women showed alkaline phosphatase (ALP) and osteocalcin (OC) serum levels significantly lower than controls, while no differences were found in fasting urinary calcium and hydroxyproline excretion. Women without fractures showed a significant correlation between ALP and both age and years since menopause (YSM). Such a correlation is lacking in the fracture group.Women with vertebral deformities likely due to a fracture had a forearm BMD and markers of bone formation lower than normal. Whether low bone density is due to a low peak of bone mass or to an increased postmenopausal bone loss sustained by an uncoupling between the two bone remodelling processes is still unclear. |
| Databáze: | OpenAIRE |
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