Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage
| Autor: | Ren-Jei Chung, Yang Wei, Xiao-Juan Huang, Yi-Shi Hwua, Tsai-Hsueh Leu, Jung-Tang Huang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Fabrication
Materials science Polymers and Plastics Osteoporosis Composite number polymethyl-methacrylate bone cement poly-l-lactic acid 02 engineering and technology 03 medical and health sciences 0302 clinical medicine kyphoplasty medicine Spinal canal Leakage (electronics) technology industry and agriculture General Chemistry equipment and supplies 021001 nanoscience & nanotechnology medicine.disease Bone cement medicine.anatomical_structure tricalcium silicate 030220 oncology & carcinogenesis barrier Composite membrane 0210 nano-technology Biomedical engineering Tricalcium silicate |
| Zdroj: | Polymers Volume 11 Issue 12 |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym11121971 |
| Popis: | Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice. |
| Databáze: | OpenAIRE |
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