Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau
| Autor: | Yakun Tian, Hou Hon Cheong, Xu Zhong, Iek Long Lo, Nin Ngan Sin, Tak Hong Cheong, Chin Ion Lei, Chon Fu Lio |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Urine Applied Microbiology and Biotechnology Feces COVID-19 Testing Nasopharynx Medicine stool Lung 0303 health sciences Reverse Transcriptase Polymerase Chain Reaction Middle Aged nasopharyngeal swab Virus Shedding Diarrhea RNA Viral Female Radiography Thoracic medicine.symptom Coronavirus Infections Research Paper Adult medicine.medical_specialty COVID-19 Vaccines Fever Pneumonia Viral novel coronavirus Real-Time Polymerase Chain Reaction Virus 03 medical and health sciences Betacoronavirus Internal medicine Humans Viral shedding Molecular Biology Pandemics Ecology Evolution Behavior and Systematics 030304 developmental biology Retrospective Studies Macau business.industry Clinical Laboratory Techniques SARS-CoV-2 Sputum Outbreak COVID-19 Retrospective cohort study qRT-PCR Cell Biology COVID-19 Drug Treatment business Tomography X-Ray Computed Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | As a city famous for tourism, the public healthcare system of Macau SAR has been under great pressure during the outbreak of the Coronavirus Disease 2019 (COVID-19). In this study, we report clinical and microbiological features of ten COVID-19 patients enrolled in the Centro Hospitalar Conde de Sao Januario (CHCSJ) between January 21 to February 16, 2020. Clinical samples from all patients including nasopharyngeal swab (NPS)/sputum, urine, and feces were collected for serial virus RNA testing by standard qRT-PCR assay. In total, seven were imported cases and three were local cases. The median duration from Macau arrival to admission in imported cases was 3 days. Four patients required oxygen therapy but none of them needed machinal ventilation. No fatal cases were noted. The most common symptoms were fever (80%) and diarrhea (80%). In the "Severe" group, there was significantly more elderly patients (p=0.045), higher lactate dehydrogenase levels (p=0.002), and elevated C-Reactive protein levels compared to the "Mild to Moderate" group (p |
| Databáze: | OpenAIRE |
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