Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects
| Autor: | Alessandra R. Pinheiro-Mulder, Grazielle Vilas Bôas Huguenin, Tatiana D. Saint'Pierre, Glorimar Rosa, Gláucia Maria Moraes de Oliveira, Ronir Raggio Luiz, Annie Seixas Bello Moreira, Anderson Junger Teodoro, Rodrigo A. Gonçalves |
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| Rok vydání: | 2015 |
| Předmět: |
Male
GPX3 Medicine (miscellaneous) Blood lipids Blood Pressure Antioxidants Body Mass Index chemistry.chemical_compound Surveys and Questionnaires Nuts Brazil nut chemistry.chemical_classification Cross-Over Studies Nutrition and Dietetics Glutathione peroxidase Middle Aged Hypertension Female medicine.medical_specialty Nutritional Status Clinical nutrition Selenium food Double-Blind Method Internal medicine medicine Humans Serum lipids Triglycerides Aged Dyslipidemias Glutathione Peroxidase Cholesterol business.industry Research Body Weight Cholesterol HDL Cholesterol LDL medicine.disease Crossover study food.food Diet Oxidative Stress Endocrinology Dyslipidemia chemistry Bertholletia Linear Models business Biomarkers |
| Zdroj: | Nutrition Journal |
| ISSN: | 1475-2891 |
| DOI: | 10.1186/s12937-015-0043-y |
| Popis: | To investigate the effect of partially defatted Granulated Brazil nut (GBN) on biomarkers of oxidative stress and antioxidant status of hypertensive and dyslipidemic patients on nutrition and drug approaches. Ninety one hypertensive and dyslipidemic subjects of both genders (51.6 % men), mean age 62.1 ± 9.3 years, performed a randomized crossover trial, double-blind, placebo controlled. Subjects received a diet and partially defatted GBN 13 g per day (≈227.5 μg/day of selenium) or placebo for twelve weeks with four-week washout interval. Anthropometric, laboratory and clinic characteristics were investigated at baseline. Plasma selenium (Se), plasma glutathione peroxidase (GPx3) activity, total antioxidant capacity (TAC), 8-epi PGF2α and oxidized LDL were evaluated at the beginning and in the end of each intervention. GBN intake significantly increased plasma Se from 87.0 ± 16.8 to 180.6 ± 67.1 μg/L, increased GPx3 activity in 24,8 % (from 112.66 ± 40.09 to 128.32 ± 38.31 nmol/min/mL, p |
| Databáze: | OpenAIRE |
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