Replication stalling and DNA microsatellite instability
| Autor: | Todd Lewis, Joanna Barthelemy, Michael Leffak, Rujuta Yashodhan Gadgil |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
DNA Replication
0301 basic medicine Genome instability Biophysics Biology Biochemistry Article 03 medical and health sciences chemistry.chemical_compound medicine Humans DNA Breaks Double-Stranded Nucleotide Genetics Double strand chemistry.chemical_classification Organic Chemistry DNA replication Microsatellite instability medicine.disease 030104 developmental biology chemistry Microsatellite Microsatellite Instability Human genome DNA Microsatellite Repeats |
| Zdroj: | Biophysical Chemistry. 225:38-48 |
| ISSN: | 0301-4622 |
| DOI: | 10.1016/j.bpc.2016.11.007 |
| Popis: | Microsatellites are short, tandemly repeated DNA motifs of 1–6 nucleotides, also termed simple sequence repeats (SRSs) or short tandem repeats (STRs). Collectively, these repeats comprise approximately 3% of the human genome Subramanian et al. (2003), Lander and Lander (2001) [1,2], and represent a large reservoir of loci highly prone to mutations Sun et al. (2012), Ellegren (2004) [3,4] that contribute to human evolution and disease. Microsatellites are known to stall and reverse replication forks in model systems Pelletier et al. (2003), Samadashwily et al. (1997), Kerrest et al. (2009) [5–7], and are hotspots of chromosomal double strand breaks (DSBs). We briefly review the relationship of these repeated sequences to replication stalling and genome instability, and present recent data on the impact of replication stress on DNA fragility at microsatellites in vivo. |
| Databáze: | OpenAIRE |
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