Hepatitis B Vaccine in Medical Staff of Hemodialysis Units
| Autor: | Wolf Szmuness, Cladd E. Stevens, Edward J. Harley, Edith A. Zang, Harvey J. Alter, Aaron Kellner, Anita De Vera, Patricia E. Taylor, George T. S. Chen |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty Hepatitis B vaccine medicine.medical_treatment Cross Reactions Placebo medicine.disease_cause Virus Random Allocation Double-Blind Method Internal medicine medicine Humans Hepatitis B Antibodies Hepatitis Clinical Trials as Topic business.industry Incidence (epidemiology) Viral Vaccines General Medicine Hepatitis B medicine.disease United States Occupational Diseases Personnel Hospital Hemodialysis Units Hospital Antibody Formation Immunology Female Hemodialysis business Hospital Units |
| Zdroj: | New England Journal of Medicine. 307:1481-1486 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198212093072403 |
| Popis: | We evaluated the efficacy of hepatitis B vaccine (Heptavax-B) containing only the ad subtype in a randomized, placebo-controlled, double-blind trial among 865 staff members of 43 hemodialysis units in the United States. Surface antibody developed in 92.6 per cent of the subjects after two doses of vaccine and in 96 per cent after the six-month booster. The incidence of infections with hepatitis B virus (with or without hepatitis) was 9.9 per cent in placebo recipients and 2.2 per cent in vaccine recipients (P |
| Databáze: | OpenAIRE |
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