The ADO Index as a Predictor of Two-Year Mortality in General Practice-Based Chronic Obstructive Pulmonary Disease Cohorts
| Autor: | Andreas Scherr, Jean William Fitting, David Miedinger, Milo A. Puhan, Joerg D. Leuppi, Salome Schafroth Török, Anja Jochmann, Ladina Joos Zellweger, Pierre-Olivier Bridevaux, Thomas Geiser, Nebal Abu Hussein, Sabrina Maier, Robert Thurnheer, Malcolm Kohler, Prashant N Chhajed, Lucia Schoenenberger, Michael Tamm, Lara Siebeling, Gerben ter Riet |
|---|---|
| Přispěvatelé: | University of Zurich, Puhan, Milo A, Amsterdam Public Health, General practice, Amsterdam institute for Infection and Immunity |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty General Practice MEDLINE Pulmonary disease 610 Medicine & health Primary care Risk Assessment Cohort Studies Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio medicine Humans Prospective Studies 030212 general & internal medicine Intensive care medicine Prospective cohort study Aged Netherlands COPD Primary Health Care business.industry Age Factors 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) Odds ratio Middle Aged medicine.disease respiratory tract diseases 3. Good health Dyspnea 030228 respiratory system 2740 Pulmonary and Respiratory Medicine General practice Female 10178 Clinic for Pneumology business Switzerland Cohort study |
| Zdroj: | Respiration; international review of thoracic diseases, 88(3), 208-214. S. Karger AG |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000363770 |
| Popis: | Background: Existing prediction models for mortality in chronic obstructive pulmonary disease (COPD) patients have not yet been validated in primary care, which is where the majority of patients receive care. Objectives: Our aim was to validate the ADO (age, dyspnoea, airflow obstruction) index as a predictor of 2-year mortality in 2 general practice-based COPD cohorts. Methods: Six hundred and forty-six patients with COPD with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV were enrolled by their general practitioners and followed for 2 years. The ADO regression equation was used to predict a 2-year risk of all-cause mortality in each patient and this risk was compared with the observed 2-year mortality. Discrimination and calibration were assessed as well as the strength of association between the 15-point ADO score and the observed 2-year all-cause mortality. Results: Fifty-two (8.1%) patients died during the 2-year follow-up period. Discrimination with the ADO index was excellent with an area under the curve of 0.78 [95% confidence interval (CI) 0.71-0.84]. Overall, the predicted and observed risks matched well and visual inspection revealed no important differences between them across 10 risk classes (p = 0.68). The odds ratio for death per point increase according to the ADO index was 1.50 (95% CI 1.31-1.71). Conclusions: The ADO index showed excellent prediction properties in an out-of-population validation carried out in COPD patients from primary care settings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|