Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period
| Autor: | Yazhen Li, Ping He, Chun Lin, Xiao-yang Jiao, Changwen Ke, Huanzhu Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male China Community-acquired pneumonia Adolescent Klebsiella pneumoniae Immunology Respiratory virus Real-Time Polymerase Chain Reaction Microbiology Virus Article Young Adult bacterial/Yeast infection Influenza Human medicine Immunology and Allergy Humans Child Aged Aged 80 and over General Veterinary biology Co-infections Coinfection Infant Newborn Infant General Medicine Pneumonia Middle Aged biology.organism_classification medicine.disease Influenza Acinetobacter baumannii Klebsiella Infections Community-Acquired Infections Infectious Diseases medicine.anatomical_structure Mycoses Child Preschool Etiology Female Respiratory tract Acinetobacter Infections |
| Zdroj: | Comparative Immunology, Microbiology and Infectious Diseases |
| ISSN: | 1878-1667 0147-9571 |
| Popis: | Highlights • 1 Not all patients (only 123(63.08%)) have definitely pathogens found. • 2 Non-influenza patients’ co-infection were more common in the peak of Influenza. • 3 The pattern of co-infection in our study is different from previous study. • 4 Yeast, Acinetobacter baumannii and Klebsiella pneumoniae have high positive rate. Purpose The etiology of community-acquired pneumonia (CAP) in hospital patients is often ambiguous due to the limited pathogen detection. Lack of a microbiological diagnosis impairs precision treatment in CAP. Methods Specimens collected from the lower respiratory tract of 195 CAP patients, viruses were measured by the Single-plex real-time PCR assay and the conventional culture method was exploited for bacteria. Results Among the 195 patients, there were 46 (23.59%) pure bacterial infections, 20 (10.26%) yeast infections, 32 (16.41%) pure viral infections, 8 (4.10%) viral-yeast co-infections, and 17 (8.72%) viral-bacterial co-infections. The two most abundant bacteria were Acinetobacter baumannii and klebsiella pneumoniae, whereas the most common virus was influenza A. Conclusions Non-influenza respiratory microorganisms frequently co-circulated during the epidemic peaks of influenza, which easily being ignored in CAP therapy. In patients with bacterial and viral co-infections, identifying the etiologic agent is crucial for patient’s therapy. |
| Databáze: | OpenAIRE |
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