HSP60 in cancer: a promising biomarker for diagnosis and a potentially useful target for treatment
| Autor: | Bo Sun, Dongchun Liu, Qing Yu, Xing Tang, Ganghui Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmaceutical Science
Apoptosis chemical and pharmacologic phenomena 02 engineering and technology Mitochondrial Proteins 03 medical and health sciences 0302 clinical medicine Neoplasms Heat shock protein Biomarkers Tumor Humans Medicine Heat-Shock Proteins Physiological stress business.industry fungi food and beverages Cancer Chaperonin 60 021001 nanoscience & nanotechnology medicine.disease female genital diseases and pregnancy complications 030220 oncology & carcinogenesis Cancer research Biomarker (medicine) HSP60 0210 nano-technology business |
| Zdroj: | Journal of Drug Targeting. 30:31-45 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.1080/1061186x.2021.1920025 |
| Popis: | Heat shock proteins (HSPs), most of which are molecular chaperones, are highly conserved proteins produced by cells under physiological stress or pathological conditions. HSP60 (57-69 kDa) can promote or inhibit cell apoptosis through different mechanisms, and its abnormal expression is also related to tumour cell metastasis and drug resistance. In recent years, HSP60 has received increasing attention in the field of cancer research due to its potential as a diagnostic and prognostic biomarker or therapeutic target. However, in different types of cancer, the specific mechanisms of abnormally expressed HSP60 in tumour carcinogenesis and drug resistance are complicated and still require further study. In this article, we comprehensively review the regulative mechanisms of HSP60 on apoptosis, its applications as a cancer diagnostic biomarker and a therapeutic target, evidence of involvement in tumour resistance and the applications of exosomal HSP60 in liquid biopsy. By evaluating the current findings of HSP60 in cancer research, we highlight some core issues that need to be addressed for the use of HSP60 as a diagnostic or prognostic biomarker and therapeutic target in certain types of cancer. |
| Databáze: | OpenAIRE |
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