Development of the Endochondral Skeleton
| Autor: | David M. Ornitz, Fanxin Long |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Cellular differentiation SOX9 Biology Fibroblast growth factor Models Biological General Biochemistry Genetics and Molecular Biology Chondrocyte Mice Chondrocytes Osteogenesis Internal medicine medicine Animals Humans Growth Plate Endochondral ossification Transcription factor Osteoblasts Models Genetic Concept Gene Expression Regulation Developmental Osteoblast Cell Differentiation Cell biology RUNX2 medicine.anatomical_structure Endocrinology embryonic structures Signal Transduction Transcription Factors |
| Popis: | Much of the mammalian skeleton is composed of bones that originate from cartilage templates through endochondral ossification. Elucidating the mechanisms that control endochondral bone development is critical for understanding human skeletal diseases, injury response, and aging. Mouse genetic studies in the past 15 years have provided unprecedented insights about molecules regulating chondrocyte formation, chondrocyte maturation, and osteoblast differentiation, all key processes of endochondral bone development. These include the roles of the secreted proteins IHH, PTHrP, BMPs, WNTs, and FGFs, their receptors, and transcription factors such as SOX9, RUNX2, and OSX, in regulating chondrocyte and osteoblast biology. This review aims to integrate the known functions of extracellular signals and transcription factors that regulate development of the endochondral skeleton. |
| Databáze: | OpenAIRE |
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