Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives

Autor:	Beatrice Felber, Christian Hartung, Alexander Backes, Andrea Missio, Alexander Philipp
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Pyrimidine chemistry Organic Chemistry Drug Discovery Organic chemistry Surface modification General Medicine Combinatorial chemistry Biochemistry Microwave assisted Amination
Zdroj:	Tetrahedron. 62:10055-10064
ISSN:	0040-4020
Popis:	A generally applicable one-pot procedure for the rapid, easy, and diverse asymmetric functionalization of pyrimidines was developed that requires minimum efforts for the purification of the final products. 4-Amino-6-aryl-substituted pyrimidines are prepared in good yields by combined microwave-assisted amination and Suzuki–Miyaura cross-coupling reactions. The acid-mediated amination reaction affords the products as easily separable salts in 30–40 min reaction time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318d68a5bd3528fc6481b97946220cb https://doi.org/10.1016/j.tet.2006.08.065 Zobrazit plný text záznamu Full Text from ScienceDirect