Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis
| Autor: | Aline Ávila Brustolin, Jorge Juarez Vieira Teixeira, Jully Oyama, Luciana Dias Ghiraldi Lopes, Thais da Silva Santos, Mariana de Souza Terron Monich, Letícia Sayuri Murase, Thaís Gomes Verzignassi Silveira, Camila Alves Mota, João Vítor Perez de Souza |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Immunology Antiprotozoal Agents Treatment failure 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Humans In patient Leishmaniasis Leishmaniasis Vaccines Chemotherapy business.industry Immunotherapy medicine.disease Clinical trial 030104 developmental biology Visceral leishmaniasis 030220 oncology & carcinogenesis Meta-analysis business |
| Zdroj: | Immunotherapy. 13(8) |
| ISSN: | 1750-7448 |
| Popis: | Aim: Current treatments for leishmaniases are not satisfactory, thus alternatives are needed. We searched for clinical trials with immunotherapeutic approaches for patients with leishmaniasis. Materials & methods: Out of 205 articles, 24 clinical trials were selected, and eight submitted to meta-analysis. Results: A reduction in healing time was observed in patients with tegumentary leishmaniasis treated with pentavalent antimony plus granulocyte-macrophage colony-stimulating factor, and therapeutic vaccines. Overall meta-analysis indicated that immunotherapy associated with the standard chemotherapy generated a significantly reduced risk of treatment failure than the pentavalent antimony alone (p = 0.03). Conclusion: Our review confirmed the efficacy of immunotherapies for the treatment of cutaneous and visceral leishmaniasis and highlighted the importance of clinical trials using immunotherapies for leishmaniases. |
| Databáze: | OpenAIRE |
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