Effect of chronic naltrexone administration and its withdrawal on the regional activity of neurons that contain norepinephrine, dopamine and serotonin
| Autor: | Alan R. Gintzler, Tarak Sharma, Wai C. Chan |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Serotonin
Dopamine Thalamus Pharmacology Naltrexone Norepinephrine Monoaminergic medicine Animals Molecular Biology Neurons Narcotic antagonist Chemistry General Neuroscience Brain Rats Inbred Strains Rats Substance Withdrawal Syndrome nervous system Opioid Organ Specificity Female Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 442:379-386 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(88)91530-2 |
| Popis: | A method is described that permits the simultaneous quantitation of norepinephrine (NE), dopamine (DA) serotonin (5-HT) and their respective major metabolites, 3-methoxy-4-hydroxy phenylglycol (MHPG), 3-methoxytyramine (3-MT), dihydroxyphenyl acetic acid (DOPAC) and 5-hydroxyindole acetic acid (5-HIAA) in discrete brain regions. The ratio of MHPG/NE, DOPAC/DA and 5-HIAA/5-HT was used to assess the effects of the chronic administration of the narcotic antagonist, naltrexone, and its withdrawal on the regional activity of neurons that contain NE, DA and 5-HT respectively. Chronic administration of naltrexone (8 days) is associated with a significant increase in the ratio of 5-HIAA/5-HT and DOPAC/DA in the frontal cortex and dorsal hippocampus respectively. Under this condition the thalamic concentration of 3-MT in 4 of 8 animals is also significantly elevated. In contrast, the mesolimbic forebrain exhibited a decrease in the MHPG/NE ratio (4 out of 8 animals). One day following naltrexone pellet removal the above ratios, as well as the mean content of 3-MT in the thalamus, returned to control values. At this time the content of 3-MT in the thalamus (5 of 5 animals) and frontal cortex (3 of 9 rats) was appreciably elevated, while its content in the dorsal hippocampus was significantly reduced (6 of 9 rats). These data suggest that the activity of several central monoaminergic neuronal systems are regulated by an opioid input that is tonically active. |
| Databáze: | OpenAIRE |
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