Biomarkers of Acromegaly and Growth Hormone Action
| Autor: | Carlo Cappelli, Letizia Chiara Pezzaioli, Filippo Maffezzoni, Andrea Delbarba, Alberto Ferlin, Teresa Porcelli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male GH deficit Hormone Replacement Therapy 030209 endocrinology & metabolism Bioinformatics Growth hormone Biochemistry Growth hormone deficiency Disease activity 03 medical and health sciences 0302 clinical medicine Acehytisine hydrochloride QSAR acromegaly anti-arrhythmic drugs biomarkers cancer hERG insulin-like growth factor-I miRNA van der Waals Structural Biology Acromegaly medicine Humans Insulin-Like Growth Factor I Child Pathological Human Growth Hormone business.industry General Medicine medicine.disease Drug development 030220 oncology & carcinogenesis Potential biomarkers Female Gh replacement business |
| Zdroj: | Protein & Peptide Letters. 27:1231-1245 |
| ISSN: | 0929-8665 |
| DOI: | 10.2174/0929866527666200420103816 |
| Popis: | Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. : Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. : However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. : The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse. |
| Databáze: | OpenAIRE |
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