The cytoplasmic dynein transport machinery and its many cargoes
| Autor: | William B. Redwine, Ronald D. Vale, Samara L. Reck-Peterson, Andrew P. Carter |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cytoplasmic Dyneins Cell division 1.1 Normal biological development and functioning Dynein Motility macromolecular substances Biology Microtubules Medical and Health Sciences Article 03 medical and health sciences Rare Diseases Microtubule Underpinning research Cell Movement Organelle Animals Humans Molecular Biology Organelles Biological Transport Cell Biology Dynactin Complex Biological Sciences BICD2 Cell biology 030104 developmental biology Generic Health Relevance Dynactin Interphase Developmental Biology |
| Zdroj: | Reck-Peterson, SL; Redwine, WB; Vale, RD; & Carter, AP. (2018). The cytoplasmic dynein transport machinery and its many cargoes. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 19(6), 382-398. doi: 10.1038/s41580-018-0004-3. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0h227304 Nature reviews. Molecular cell biology, vol 19, iss 6 |
| Popis: | Cytoplasmic dynein-1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here we focus on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses. A central challenge in the field is to understand how a single motor can transport such a diverse array of cargoes and how this process is regulated. The molecular basis by which each cargo is linked to dynein and its cofactor dynactin has started to emerge. Of particular importance for this process is a set of coiled coil proteins — ‘activating adaptors’ — which both recruit dynein–dynactin to their cargoes and activate dynein motility. |
| Databáze: | OpenAIRE |
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