Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents
| Autor: | Shigeyuki Chaki, Yoshiko Suzuki, Toshiharu Shimazaki, Shigeru Okuyama, Naoya Kawashima |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Nerve Tissue Proteins FG-7142 Pharmacology Anxiety Cocaine and amphetamine regulated transcript Buspirone Membrane Potentials GABA Antagonists chemistry.chemical_compound Mice immune system diseases Internal medicine mental disorders medicine Inverse agonist Animals Maze Learning Social Behavior Injections Intraventricular Neurons Benzodiazepine Mice Inbred ICR Diazepam Behavior Animal Dose-Response Relationship Drug GABAA receptor virus diseases Peptide Fragments Endocrinology nervous system chemistry Anti-Anxiety Agents Locus coeruleus Locus Coeruleus Psychology hormones hormone substitutes and hormone antagonists Injections Intraperitoneal medicine.drug Carbolines |
| Zdroj: | European journal of pharmacology. 464(1) |
| ISSN: | 0014-2999 |
| Popis: | Cocaine- and amphetamine-regulated transcript (CART) peptide (CART-(55–102)) is involved in the suppression of food intake. We now report that CART-(55–102) is involved in anxiety in rodents. Intracerebroventricularly administered CART-(55–102) as well as intraperitoneal administration of N-methyl-β-carboline-3-carboxamide (FG-7142), a selective GABAA/benzodiazepine receptor inverse agonist, reduced time spent in the open arms in the elevated plus-maze task in mice. CART-(55–102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone. Likewise, CART-(55–102) and FG-7142 significantly reduced social interaction in mice. Both diazepam and buspirone significantly reversed CART-(55–102)-induced anxiogenic-like behavior in social interaction tests. By contrast, another biologically active CART peptide, CART-(62–102), was without effect in the elevated plus-maze task in mice. Moreover, intracerebroventricular administration of CART-(55–102) markedly increased the firing rate of locus coeruleus neurons in single unit recording in anesthetized rats. As CART-(55–102) produced anxiety-like effects in rodents, this peptide may possibly be involved in anxiety and stress-related behavior. |
| Databáze: | OpenAIRE |
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