Physical, Chemical and Biological Characterization of Natural Rubber Latex Membranes Loaded with Cordia verbenacea DC. Extract

Autor: Matheus Carlos Romeiro Miranda, Vitoria de Sousa chao, Rondinelli Donizetti Herculano, André Gonzaga dos Santos, Bruna Cambraia Garms, Juliana Ferreira Floriano, C. G. Paulino, Monica Yonashiro Marcelino, Felipe Azevedo Borges, Natan Roberto de Barros, Carlos Frederico de Oliveira Graeff, Ana Laura Destro Chagas, Luis Felipe Cesar Bolognesi, Ana Maria Q. Norberto, Juhan A. S. Pereira
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP)
Rok vydání: 2018
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 2215-0838
Popis: Made available in DSpace on 2019-10-04T12:32:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) PADC/FCF-UNESP Background and Objective: Cordia verbenacea DC (C. verbenacea) extract has been widely used in Brazilian traditional medicine to treat topical inflammatory processes and has shown healing activity. Moreover, the extract showed activity against coli and Staphylococcus aureus strains. Natural Rubber Latex (NRL) membrane has a potential to stimulate wound healing process, to accelerate healing of cutaneous chronic ulcers in humans, cellular adhesion and increase vascularization Recent studies have used the NRL for Drug Delivery Systems (DDS). In this work, it was developed an NRL membrane was developed containing C. verbenacea using NRL as a carrier and physical, chemical and biological characterization were performed to evaluate its potential as a system release of extract for DDS. Fourier transform infrared spectroscopy (FTIR) showed no chemical interactions between the extract and NRL, which influence its mechanical behavior. C. verbenacea was adsorbed by the NRL membrane along all of its surface. Conclusion: Kinetic release profile showed that NRL membrane can release the extract for up to 18% during 80 hours and it obeys a bi-exponential function. In vitro cytotoxicity and hemolysis assay showed that the extract loaded NRL membrane presented no cell damage effects and no cytotoxicity at a concentration of 100-10%. The results showed that the NRL membrane is a potential and effective model of C. verbenacea release. Sao Paulo State Univ, Dept Phys, Sch Sci, 14-01 Luiz Edmundo Carrijo Coube Ave, BR-17033360 Bauru, SP, Brazil Sao Paulo State Univ, Sch Sci & Languages, Dept Biol Sci, 210 Dom Antonio Ave, BR-19806900 Assis, SP, Brazil Sao Paulo State Univ, Inst Chem, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, Brazil Sao Paulo State Univ, Sch Pharmaceut Sci, Bioengenering & Biomat Grp, Km 01 Araraquara Jau Rd, BR-14801902 Araraquara, SP, Brazil Univ Sao Paulo, Dept Clin Med, Fac Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto, SP, Brazil Sao Paulo State Univ, Dept Phys, Sch Sci, 14-01 Luiz Edmundo Carrijo Coube Ave, BR-17033360 Bauru, SP, Brazil Sao Paulo State Univ, Sch Sci & Languages, Dept Biol Sci, 210 Dom Antonio Ave, BR-19806900 Assis, SP, Brazil Sao Paulo State Univ, Inst Chem, 55 Prof Francisco Degni St, BR-14800060 Araraquara, SP, Brazil Sao Paulo State Univ, Sch Pharmaceut Sci, Bioengenering & Biomat Grp, Km 01 Araraquara Jau Rd, BR-14801902 Araraquara, SP, Brazil CNPq: 470261/2012-9 FAPESP: 2011/17411-8 FAPESP: 2014/17526-8 FAPESP: 2014/11037-5 PADC/FCF-UNESP: 2015/04-I
Databáze: OpenAIRE
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