Evidence that inhibitory motor neurons of the guinea-pig small intestine exhibit fast excitatory synaptic potentials mediated via P2X receptors
| Autor: | Peter D. J. Thornton, Joel C. Bornstein, P. J. Johnson, Omar R. Shum |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Guinea Pigs Myenteric Plexus Biology Neurotransmission Inhibitory postsynaptic potential chemistry.chemical_compound Ileum medicine Animals Myenteric plexus Motor Neurons Receptors Purinergic P2 musculoskeletal neural and ocular physiology General Neuroscience Excitatory Postsynaptic Potentials Motor neuron Electrophysiology medicine.anatomical_structure nervous system chemistry Excitatory postsynaptic potential Enteric nervous system Hexamethonium Female Neuroscience |
| Zdroj: | Neuroscience letters. 266(3) |
| ISSN: | 0304-3940 |
| Popis: | Intracellular recordings were used to study the contribution of nicotinic and P2X receptors to synaptic transmission to morphologically identified myenteric neurons of guinea-pig ileum. Hexamethonium (100 microM) abolished fast excitatory synaptic potentials (EPSPs) in all orally projecting neurons, but fast EPSPs in anally projecting neurons were resistant to this antagonist. The non-cholinergic fast EPSPs were virtually abolished by suramin (100 microM). This suggests that P2X receptors are important in descending motility reflexes. However, suramin and hexamethonium together did not affect descending inhibitory reflexes when applied to the site of transmission between interneurons in this pathway. These data suggest that P2X receptors are not involved in transmission between descending interneurons, but may be important for transmission to inhibitory motor neurons. |
| Databáze: | OpenAIRE |
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