Efficacy of a hypolipid diet in patients with primary antiphospholipid syndrome with dyslipidemia: a prospective study
| Autor: | Marcos Aurelio Pereira, Joyce M. Annichino-Bizzacchi, Sabrina da Silva Saraiva, Camila de Oliveira Vaz, Fernanda Andrade Orsi, Eliana C M Miranda, Thays de Cássia Ruiz Rodrigues, Bruna M Mazetto |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Diet therapy Population Gastroenterology chemistry.chemical_compound Antiphospholipid syndrome Internal medicine medicine Humans Prospective Studies education Prospective cohort study Dyslipidemias education.field_of_study Cholesterol business.industry Cholesterol HDL Hematology Antiphospholipid Syndrome medicine.disease Lipids Obesity Diet chemistry Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Body mass index Dyslipidemia |
| Zdroj: | Journal of Thrombosis and Thrombolysis. 53:390-398 |
| ISSN: | 1573-742X 0929-5305 |
| DOI: | 10.1007/s11239-021-02542-z |
| Popis: | Although dyslipidemia is associated with poorer prognosis in antiphospholipid syndrome (APS), the management of lipid disorders can be challenging. While statins may increase the bleeding risk associated with anticoagulation, the effectiveness of hypolipid diet (HD) has not yet been established in patients with autoimmune disorders. In this study, we evaluated whether HD is associated with decreases in cholesterol levels in patients with thrombotic primary APS (t-PAPS) and dyslipidemia. Nutritional and lipid profiles were assessed before HD was initiated (baseline) and after 3 and 6 months with HD. A 24-h dietary recall was applied to assess the adherence to the diet. Forty-four patients were included, mean age was 43 years (± 12.93) and 65% were female. After HD was started, the intake of carbohydrates, lipids, saturated fats and cholesterol decreased, whereas dietary fiber intake increased. Levels of total cholesterol (TC) and non-high density lipoprotein cholesterol (non-HDL-C) decreased after 3 and 6 months of HD, as compared to baseline (P = 0.007 and P = 0.008). Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) values did not change during the study period. The mean body mass index (BMI) decreased from 28.4 to 27.8 kg/m2 after six months of HD (p |
| Databáze: | OpenAIRE |
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