Finite Element Analysis of the Microwave Ablation Method for Enhanced Lung Cancer Treatment
| Autor: | Branislav Radjenović, Marta Prnova, Marija Radmilovic-Radjenovic, Lukáš Šoltés, Martin Sabo |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Materials science medicine.medical_treatment Relative permittivity Dielectric Electromagnetic radiation Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine RC254-282 Microwave ablation Neoplasms. Tumors. Oncology. Including cancer and carcinogens Specific absorption rate tissue Dissipation Ablation Finite element method lung cancer Oncology dielectric properties microwave ablation 030220 oncology & carcinogenesis damage Biomedical engineering |
| Zdroj: | Cancers Volume 13 Issue 14 Cancers, Vol 13, Iss 3500, p 3500 (2021) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13143500 |
| Popis: | Knowledge of the frequency dependence of the dielectric properties of the lung tissues and temperature profiles are essential characteristics associated with the effective performance of microwave ablation. In microwave ablation, the electromagnetic wave propagates into the biological tissue, resulting in energy absorption and providing the destruction of cancer cells without damaging the healthy tissue. As a consequence of the respiratory movement of the lungs, however, the accurate prediction of the microwave ablation zone has become an exceptionally demanding task. For that purpose, numerical modeling remains a primordial tool for carrying out a parametric study, evaluating the importance of the inherent phenomena, and leading to better optimization of the medical procedure. This paper reports on simulation studies on the effect of the breathing process on power dissipation, temperature distribution, the fraction of damage, and the specific absorption rate during microwave ablation. The simulation results obtained from the relative permittivity and conductivity for inflated and deflated lungs are compared with those obtained regardless of respiration. It is shown that differences in the dielectric properties of inflated and deflated lungs significantly affect the time evolution of the temperature and its maximum value, the time, the fraction of damage, and the specific absorption rate. The fraction of damage determined from the degree of tissue injury reveals that the microwave ablation zone is significantly larger under dynamic physical parameters. At the end of expiration, the ablation lesion area is more concentrated around the tip and slot of the antenna, and the backward heating effect is smaller. The diffuse increase in temperature should reach a certain level to destroy cancer cells without damaging the surrounding tissue. The obtained results can be used as a guideline for determining the optimal conditions to improve the overall success of microwave ablation. |
| Databáze: | OpenAIRE |
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