The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
| Autor: | Mohini Gray, Karen E. Chapman, John Savill, James S. Gilmour, Agnes E. Coutinho, Jonathan R. Seckl |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Transcription Genetic Arthritis 030209 endocrinology & metabolism Inflammation Biochemistry Gene Expression Regulation Enzymologic 03 medical and health sciences 0302 clinical medicine Endocrinology 11β-hydroxysteroid dehydrogenase type 1 Internal medicine 11-beta-Hydroxysteroid Dehydrogenase Type 1 medicine Animals Humans Molecular Biology Glucocorticoids ComputingMilieux_MISCELLANEOUS 030304 developmental biology Regulation of gene expression 0303 health sciences biology business.industry Life Sciences medicine.disease 3. Good health Rheumatoid arthritis biology.protein Cortisone medicine.symptom business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug Hormone |
| Zdroj: | Molecular and Cellular Endocrinology Molecular and Cellular Endocrinology, Elsevier, 2009, 301 (1-2), pp.123. ⟨10.1016/j.mce.2008.09.031⟩ |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2008.09.031⟩ |
| Popis: | Cortisone, a glucocorticoid hormone, was first used to treat rheumatoid arthritis in humans in the late 1940s, for which Hench, Reichstein and Kendall were awarded a Nobel Prize in 1950 and which led to the discovery of the anti-inflammatory effects of glucocorticoids. To be effective, the intrinsically inert cortisone must be converted to the active glucocorticoid, cortisol, by the intracellular action of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Whilst orally administered cortisone is rapidly converted to the active hormone, cortisol, by first pass metabolism in the liver, recent work has highlighted an anti-inflammatory role for 11beta-HSD1 within specific tissues, including in leukocytes. Here, we review recent evidence pertaining to the anti-inflammatory role of 11beta-HSD1 and describe how inhibition of 11beta-HSD1, as widely proposed for treatment of metabolic disease, may impact upon inflammation. Finally, the mechanisms that regulate 11beta-HSD1 transcription will be discussed. |
| Databáze: | OpenAIRE |
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