Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population

Autor:	Xiuxiu Chen, Huangfu Wu, Guisheng He, Huamin Chen, Tao Song, Yunjing Chen, Chaoyang Zhao, Yazhen Zhang, Chuanwei Sun, Wei Xiong
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Oncology medicine.medical_specialty lcsh:QH426-470 Breast Neoplasms 030105 genetics & heredity Polymorphism Single Nucleotide susceptibility polymorphism 03 medical and health sciences Breast cancer breast cancer Asian People Internal medicine Genotype Genetic model Genetics medicine Humans Genetic Predisposition to Disease Breast Allele Molecular Biology Alleles Genetics (clinical) GALNT16 Chinese population Tumor size business.industry Original Articles Odds ratio Middle Aged medicine.disease Confidence interval Tumor Burden lcsh:Genetics 030104 developmental biology Case-Control Studies Lymphatic Metastasis N-Acetylgalactosaminyltransferases Female Original Article business
Zdroj:	Molecular Genetics & Genomic Medicine, Vol 7, Iss 8, Pp n/a-n/a (2019) Molecular Genetics & Genomic Medicine
ISSN:	2324-9269
Popis:	Background Polypeptide N‐acetylgalactosaminyltransferase 16 (GALNT16) is an N‐acetylgalactosaminyltransferase gene that alters protein O‐glycosylation, which plays a role in tumor development. This study aims to explore the association of eight GALNT16 polymorphisms with susceptibility to breast cancer (BC). Methods This case–control study included 563 BC patients and 552 age‐matched healthy controls from the Chinese Han population. The genotypes of GALNT16 polymorphisms were detected using the Agena MassARRAY. The relationship between GALNT16 polymorphisms and BC risk was evaluated using a chi‐squared test with an odds ratio (OR) and 95% confidence intervals (CI) under five genetic models. Results We observed that rs2105269 and rs72625676 were associated with higher BC risk in younger patients with age ≤51 (rs2105269, codominant: p = .006; recessive: p = .005 additive: p = .018; and allele: p = .012; rs72625676, codominant: p = .038; recessive: p = .037). For rs1275678 polymorphism, there was a significantly decreased risk of BC among elder patients (codominant: p = .017; dominant: p = .019; additive: p = .030; and allele: p = .029). Further analysis by clinical characteristics showed rs2105269 was associated with tumor size and lymph node metastasis. Conclusion Our study suggests that GALNT16 polymorphisms are associated with BC susceptibility in Chinese population.
Databáze:	OpenAIRE
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