TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)
| Autor: | Yongbin Hu, Zhimin Ye |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
MAPK/ERK pathway
MAP Kinase Signaling System medicine.medical_treatment SMAD Disease Mitochondrial Proteins Transforming Growth Factor beta1 Idiopathic pulmonary fibrosis Fibrosis TGF-β1 Genetics Humans Medicine Lung transplantation Smad business.industry Articles General Medicine respiratory system idiopathic pulmonary fibrosis medicine.disease MAPK humanities respiratory tract diseases ERK Cancer research Signal transduction Apoptosis Regulatory Proteins business Signal Transduction Transforming growth factor |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and irreversible decline of lung function. Currently, there is no drug to successfully treat the disease except for lung transplantation. Numerous studies have been devoted to the study of the fibrotic process of IPF and findings showed that transforming growth factor‑β1 (TGF‑β1) plays a central role in the development of IPF. TGF‑β1 promotes the fibrotic process of IPF through various signaling pathways, including the Smad, MAPK, and ERK signaling pathways. There are intersections between these signaling pathways, which provide new targets for researchers to study new drugs. In addition, TGF‑β1 can affect the fibrosis process of IPF by affecting oxidative stress, epigenetics and other aspects. Most of the processes involved in TGF‑β1 promote IPF, but TGF‑β1 can also inhibit it. This review discusses the role of TGF‑β1 in IPF. |
| Databáze: | OpenAIRE |
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