Which Factors Contribute to False-Positive, False-Negative, and Invalid Results in Fetal Fibronectin Testing in Women with Symptoms of Preterm Labor?
| Autor: | Marc E. A. Spaanderman, Merel Bruijn, Jim van Eyck, Maureen T.M. Franssen, Joris A. M. van der Post, Johannes J. Duvekot, Jérôme Cornette, Frederik J.R. Hermans, Marjolein Kok, Patrick M.M. Bossuyt, Martijn A. Oudijk, Krystyna M. Sollie, Hubertina C.J. Scheepers, Frank P.H.A. Vandenbussche, Caroline J. Bax, Bas Nij Bijvank, Kitty W.M. Bloemenkamp, Anneke Kwee, Gert-Jan van Baaren, Mallory Woiski, Monique C. Haak, Femke F. Wilms, Jolande Y. Vis, Ben W.J. Mol, Martina Porath, Antoinette C. Bolte, Guid Oei |
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| Přispěvatelé: | Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrics & Gynecology, Other departments, Graduate School, Amsterdam Reproduction & Development (AR&D), Obstetrics and Gynaecology, APH - Personalized Medicine, APH - Methodology, APH - Quality of Care, Signal Processing Systems, Biomedical Diagnostics Lab, Reproductive Origins of Adult Health and Disease (ROAHD) |
| Rok vydání: | 2017 |
| Předmět: |
PHARMACOKINETICS
Pediatrics Vagina/chemistry Endosonography Obstetric Labor 0302 clinical medicine Risk Factors Pregnancy Obstetrics and Gynaecology IMPUTATION fetal fibronectin 030212 general & internal medicine False Negative Reactions Premature/diagnosis 030219 obstetrics & reproductive medicine Fetal fibronectin MISSING VALUES Coitus Obstetrics and Gynecology Gestational age Perinatology FDC-6 and Child Health Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] Vagina Female medicine.symptom preterm delivery Adult medicine.medical_specialty Gestational Age Fibronectins/analysis Lower risk Soaps 03 medical and health sciences Young Adult Obstetric Labor Premature Uterine Hemorrhage/metabolism Journal Article medicine Humans Vaginal bleeding False Positive Reactions Pediatrics Perinatology and Child Health Gynecology business.industry Other Research Radboud Institute for Health Sciences [Radboudumc 0] nutritional and metabolic diseases external factors Odds ratio prediction medicine.disease Confidence interval Fibronectins nervous system diseases Pediatrics Perinatology and Child Health Obstetric Labor Premature/diagnosis Uterine Hemorrhage business |
| Zdroj: | American Journal of Perinatology, 34, 234-239 American Journal of Perinatology, 34(3), 234-239. Thieme Medical Publishers American journal of perinatology, 34(3), 234-239. Thieme Medical Publishers American Journal of Perinatology, 34(3), 234. Thieme Medical Publishers American Journal of Perinatology, 34, 3, pp. 234-239 American Journal of Perinatology, 34(3), 234-239 American Journal of Perinatology, 34(3), 234-239. THIEME MEDICAL PUBL INC |
| ISSN: | 0735-1631 |
| Popis: | Contains fulltext : 170521.pdf (Publisher’s version ) (Closed access) Objective We assessed the influence of external factors on false-positive, false-negative, and invalid fibronectin results in the prediction of spontaneous delivery within 7 days. Methods We studied symptomatic women between 24 and 34 weeks' gestational age. We performed uni- and multivariable logistic regression to estimate the effect of external factors (vaginal soap, digital examination, transvaginal sonography, sexual intercourse, vaginal bleeding) on the risk of false-positive, false-negative, and invalid results, using spontaneous delivery within 7 days as the outcome. Results Out of 708 women, 237 (33%) had a false-positive result; none of the factors showed a significant association. Vaginal bleeding increased the proportion of positive fetal fibronectin (fFN) results, but was significantly associated with a lower risk of false-positive test results (odds ratio [OR], 0.22; 95% confidence intervals [CI], 0.12-0.39). Ten women (1%) had a false-negative result. None of the investigated factors was significantly associated with a significantly higher risk of false-negative results. Twenty-one tests (3%) were invalid; only vaginal bleeding showed a significant association (OR, 4.5; 95% CI, 1.7-12). Conclusion The effect of external factors on the performance of qualitative fFN testing is limited, with vaginal bleeding as the only factor that reduces its validity. |
| Databáze: | OpenAIRE |
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