Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor
| Autor: | Ingo Braasch, Cornelia Schmidt, Manfred Schartl, Yvonne Selz, Christina Schultheis, Jean Nicolas Volff, Carsten Hoffmann |
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| Rok vydání: | 2007 |
| Předmět: |
Molecular Sequence Data
Gene Dosage Melanoma Experimental Melanophores Oryzias Danio Cell Line Evolution Molecular Cyprinodontiformes Melanocortin receptor Sequence Analysis Protein Genetics Animals Amino Acid Sequence Cloning Molecular Zebrafish Phylogeny Melanocortins Models Genetic Sequence Homology Amino Acid biology General Medicine Xiphophorus biology.organism_classification Melanocortin 3 receptor Protein Structure Tertiary Amino Acid Substitution Melanocortin Receptor Melanocortin Type 1 Melanocortin 1 receptor |
| Zdroj: | Gene. 401:114-122 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2007.07.005 |
| Popis: | The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates. Melanocortins, the Mcr natural agonists, are pituitary peptide hormones including adrenocorticotropin and melanocyte-stimulating hormones. In mammals and birds, Mc1r is involved in pigmentation and expressed in melanocytes and melanoma. Activation of Mc1r leads to eumelanin production as well as to proliferation and survival of melanocytes in the epidermis. Here we report the molecular and evolutionary analysis of mc1r from three major fish models, the zebrafish Danio rerio, the medaka Oryzias latipes and the platyfish Xiphophorus maculatus. In contrast to some other melanocortin receptor genes, mc1r has been conserved as a single copy gene in divergent fish species. Its expression was detected in all organs tested in platyfish and medaka but was restricted to eyes, skin, brain and testis in zebrafish, this possibly reflecting differences in the distribution of extracutaneous melanophores. The mc1r gene was found to be expressed during embryogenesis, as well as in Xiphophorus hybrid melanoma, similar to human tumours. Protein sequence comparison between fish and mammalian Mc1r revealed a remarkable concordance between evolutionary and functional analyses for the identification of residues and regions critical for receptor function. |
| Databáze: | OpenAIRE |
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