Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

Autor: Francisco J. Ortega, Ana B. Fagundo, Núria Mallorquí-Bagué, José Manuel Fernández-Real, Cristina Giner-Bartolomé, Gema Frühbeck, Salomé Tárrega, Ana B. Crujeiras, Zaida Agüera, Fernando Fernández-Aranda, Cristina Botella, Armando Jesús de la Colina Rodríguez, Sarah Sauchelli, José M. Menchón, R. de la Torre, Roser Granero, Felipe F. Casanueva, María Pardo, Francisco J. Tinahones, Rosa M. Baños, Susana Jiménez-Murcia, Roser Rodríguez, José Carlos Fernández-García
Přispěvatelé: Universitat de Barcelona, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Decision
Obesitat mòrbida -- Tractament
Morbid obesity
0302 clinical medicine
Wisconsin Card Sorting Test
Obesity -- Treatment
Morbid obesity -- Treatment
Multidisciplinary
Neuropsychology
Exercici -- Aspectes fisiològics
Cognition
Middle Aged
Executive functions
Obesity
Morbid
Obesitat -- Tractament
Cognitive control
Obesitat
Female
Clinical psychology
Adult
Irisin
medicine.medical_specialty
Adolescent
Decision Making
Obesitat mòrbida
Dysfunctional profile
030209 endocrinology & metabolism
Dysfunctional family
Predictive markers
Article
03 medical and health sciences
Internal medicine
medicine
Humans
Obesity
Exercise
Physical activity
business.industry
Physical fitness
medicine.disease
Iowa gambling task
Hormones
Fibronectins
Endocrinology
business
Decision making
030217 neurology & neurosurgery
Stroop effect
Condició física
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports, núm. 6, art. 30820
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
Repositori Universitat Jaume I
Universitat Jaume I
ISSN: 2045-2322
DOI: 10.1038/srep30820
Popis: Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use. This work was supported by Instituto de Salud Carlos III (ISCIII)[FIS PI14/00290 and European Regional Development Fund (ERDF)-“a way to Build Europe”-// FONDOS FEDER “una manera de hacer Europa”] AGAUR (2009SGR1554, 2009SGR718); ABF was supported by Ministerio de Ciencia e Innovación Subprograma Juan de la Cierva (JCI-2011-09248); CGB was supported by Ayudas Predoctorales de Formación en Investigación en Salud-PFIS (FI12/00470). ABC is funded by the ISCIII through a research contract “Sara Borrell” (C09/00365). MP is a Miguel Servet Fellow (ISCIII/SERGAS). JCFG is recipient of a research contract from Servicio Andaluz de Salud (SAS) (B-0033-2014). CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and CIBER Salud Mental (CIBERsam), are supported by ISCIII.
Databáze: OpenAIRE
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