Novel self-assembled micelles based on palmitoyl-trimethyl-chitosan for efficient delivery of harmine to liver cancer
| Autor: | Yong Jin, Peng Xia, Yong-Yan Bei, Xue-nong Zhang, Qiao-Ling Zhu, Yang Liu, Xiao-Juan Hu, Chun-ge Zhang, Xiao-feng Zhou, Wei-liang Chen, Ben-gang You, Liang Zhang, Zhi-qiang Yuan |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Monoamine Oxidase Inhibitors Palmitic Acid Pharmaceutical Science Antineoplastic Agents Pharmacology Endocytosis Micelle Chitosan chemistry.chemical_compound Mice Harmine Drug Delivery Systems Liver Neoplasms Experimental In vivo Amphiphile Animals Humans Particle Size Micelles Mice Inbred BALB C Hep G2 Cells Biodegradable polymer Combinatorial chemistry In vitro chemistry Female Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Expert opinion on drug delivery. 11(6) |
| ISSN: | 1744-7593 |
| Popis: | Polymeric micelles is a safe and effective delivery system, which belong to the targeted delivery system (TDS). An anticancer drug, harmine(HM) is a hydrophobic drug with much adverse effects when used for treatment of liver cancer. Chitosan (CS) is a polysaccharide and can be modified to be an amphiphilic polmer which could self-assemble into micelles and be applied for delivery of hydrophobic drugs.To synthesize three kinds of novel biodegradable polymers, designated as palmitoyl-trimethyl-CS (TPCS)1, TPCS2 and Lac-TPCS2, and investigate their efficiency and mechanism of delivery HM to liver tumors in vitro and in viro.The self-assembled micelles presented satisfactory particle size (∼ 200 nm) and drug release characteristics in vitro. It's proved that Lac-TPCS2/HM may enter HepG2 cell through endocytosis. Antitumor experiments in vivo revealed that Lac-TPCS2/HM could significantly inhibit tumor growth and extend the lifetime of mice bearing H22 tumors after intravenous administration. Subsequently in vivo near-infrared fluorescence imaging results demonstrated a satisfactory liver tumor-targeting effect of Lac-TPCS2/HM.Three novel polymers hold great potential in the development of nanomedicine for treatment of liver tumors, in particular Lac-TPCS2 exhibits the greatest antitumor potential through active target effect. |
| Databáze: | OpenAIRE |
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