Correlation between basal insulin glargine dose required in achieving target fasting blood glucose and various clinical and laboratory parameters in hospitalized noncritical patients
| Autor: | Mitali Desai, Om J Lakhani, Surender Kumar, Chandani Seth, Sudhir Tripathi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Hospitalized patients Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Target range Gastroenterology glargine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine medicine Basal insulin hospital hyperglycemia Creatinine Insulin glargine business.industry Insulin chemistry in-hospital hyperglycemia Original Article Glycated hemoglobin Analysis of variance business medicine.drug |
| Zdroj: | Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-8210 |
| DOI: | 10.4103/ijem.ijem_297_17 |
| Popis: | Aims: The primary objective was to study the interrelationship between the basal insulin glargine dose and baseline clinical and laboratory parameters in noncritically ill hospitalized patients who have achieved the stable fasting blood glucose in the target range of 100–140 mg/dl. Patients and Methods: This was retrospective, cross-sectional, observational study. Consenting, nonpregnant, adult patients on basal-bolus insulin who had fasting capillary blood glucose in the range of 100–140 mg/dl as measured by glucometer for 3 consecutive days were included in this study. Patient receiving any basal insulin other than insulin glargine were excluded from this study. The data collected for these patients included age, sex, glycated hemoglobin (HBA1c) at the time of admission, timing of basal insulin, basal insulin dose (BID), BID/kg, weight, and serum creatinine. BID/kg was correlated with other parameters using regression analysis (Pearson's). Comparison of BID/kg in various subgroups was analyzed using Student's t- test. Parametric data of more than three groups were compared using ANOVA. The P < 0.05 was considered as statistically significant. Results: A total of 180 patients were included in the study. On correlating the BID/kg with various parameters, we found statistically significant correlation between BID/kg and glycated hemoglobin (HbA1c) at the time of admission (P = 0.044). Patients with HbA1c ≥8.0% had higher BID/kg compared to those with HbA1c |
| Databáze: | OpenAIRE |
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