Hepatobiliary dysfunction in Type-2 diabetes mellitus
Autor: | Sameer Inamdar, Ravindra Kumar, Piyush Manoria |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
nonalcoholic fatty liver disease medicine.medical_specialty lcsh:Medicine Type 2 diabetes Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Type-2 diabetes mellitus fatty liver business.industry Fatty liver lcsh:R gallstone nutritional and metabolic diseases Gallstones Odds ratio medicine.disease 030104 developmental biology Dyslipidemia 030220 oncology & carcinogenesis Original Article business Body mass index |
Zdroj: | Journal of Family Medicine and Primary Care Journal of Family Medicine and Primary Care, Vol 6, Iss 3, Pp 563-567 (2017) |
ISSN: | 2249-4863 |
Popis: | Objective: Nonalcoholic fatty liver disease (NAFLD) and gallstones are frequently present in diabetics, but its exact prevalence is not well studied in India. We have done a prevalence study of hepatobiliary involvement in Type-2 diabetes mellitus (T2DM) and also studied the other risk factors of NAFLD. Materials and Methods: Two hundred diabetics and 200 controls underwent anthropometric measurements, abdominal ultrasonography, (USG) and biochemical tests at a tertiary care hospital. Univariate and multivariate logistic regression analyses were done. Results: One hundred and thirty (65%) diabetics and 47 (23.50%) controls were having USG evidence of fatty liver (odds ratio [OR] = 6.046, 95% confidence interval [CI]: 3.904–9.363 [P < 0.0001]). Raised liver enzymes were present in 42 (21%) diabetics and 16 (8%) controls [OR = 3.057, 95% CI: 1.654–5.648 [P < 0.004]). Gallstones were present in 32 (16%) diabetics and 10 (5%) controls (OR = 2.825; 95% CI: 1.850–4.315 P < 0.0001). In addition, waist circumference (WC) and body mass index (BMI) were significantly more in diabetics, but lipid profile was not significantly deranged as compared to controls. Then, all patients with fatty liver were compared with patients with normal liver, and we found that fatty liver group was having raised BMI, WC, liver enzymes, and more dyslipidemia. Multivariate analysis was done which shows the presence of T2DM, elevated liver enzymes, obesity, and elevated WC as independent risk factors of fatty liver. Conclusion: The prevalence of NAFLD and gallstones was higher in diabetics as compared to healthy population. In addition, the presence of T2DM, elevated liver enzymes, obesity, and elevated WC are independent predictors of NAFLD. |
Databáze: | OpenAIRE |
Externí odkaz: |