Erythrocyte Carbonic Anhydrase I Concentration in Patients Receiving Thyroxine
| Autor: | Hideo Kurihara, Hiroshi Fukazawa, Kaoru Yoshinaga, Kazuro Kaise, Kyou Kikuchi, Kouki Mori, Nobuko Kaise, Yoshinori Kiso, Katsumi Yoshida |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Thyroid nodules medicine.medical_specialty Erythrocytes Radioimmunoassay Thyrotropin In Vitro Techniques Endocrinology Hypothyroidism Carbonic anhydrase Internal medicine medicine Humans Carbonic Anhydrase I Aged Carbonic Anhydrases chemistry.chemical_classification biology Thyroid General Engineering Primary hypothyroidism Middle Aged medicine.disease Thyroxine Red blood cell Enzyme medicine.anatomical_structure chemistry biology.protein Triiodothyronine Female Goiter Nodular Hormone |
| Zdroj: | Endocrinologia Japonica. 38:363-367 |
| ISSN: | 2185-6370 0013-7219 |
| Popis: | We recently reported that the red blood cell (RBC) carbonic anhydrase I (CAI) concentration in patients with hyperthyroidism is reduced and reflects the patient's mean thyroid hormone level over the preceding months. In this study, RBC CAI concentrations were measured in patients with thyroid nodules who were receiving suppressive doses of thyroxine (group I) and compared with those obtained in patients with primary hypothyroidism receiving replacement doses of thyroxine (group 2). Of the 17 patients in group 1, 16 (94%) had elevated plasma free T4 levels, but all 17 had normal free T3 levels. Of the 17 patients in group 2, 16 (94%) had normal free T4 levels and all 17 had normal free T3 levels. Plasma TSH concentrations in group 1 were all below the lower limit of sensitivity of 0.04 mU/l. In group 2, 11 had normal and 6 had slightly elevated plasma TSH concentrations. The mean (+/- SD) RBC CAI concentration in group 1 (300 +/- 53 nmol/g Hb) was significantly lower than that in group 2 (340 +/- 57 nmol/g Hb). The RBC CAI concentration was significantly correlated with both the concentration of plasma free T4 and free T3. These observations indicate that in patients receiving suppressive doses of thyroxine a slight increase in the plasma free T4 concentration produces a slight but significant decrease in RBC CAI levels. |
| Databáze: | OpenAIRE |
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