Vascular sphingolipids in physiological and pathological adaptation
| Autor: | Yu-Ting Su, Xiao-Ping Xie, Hai-Jun Zhang, Jun-Xiang Bao, Yao-Ping Cheng, Yao-Ming Chang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Cell signaling Cellular adaptation Angiogenesis Neovascularization Physiologic Apoptosis Biology 03 medical and health sciences chemistry.chemical_compound Cell Movement Animals Humans Cell Proliferation chemistry.chemical_classification Sphingolipids Reactive oxygen species Neovascularization Pathologic integumentary system Sphingosine Autophagy Compartmentalization (psychology) Atherosclerosis Adaptation Physiological Sphingolipid Cell biology 030104 developmental biology chemistry Biochemistry Hypertension Blood Vessels Reactive Oxygen Species Magnesium Deficiency |
| Zdroj: | Frontiers in Bioscience. 21:1168-1186 |
| ISSN: | 1093-4715 1093-9946 |
| DOI: | 10.2741/4448 |
| Popis: | Sphingolipids (SLs) are compounds containing a long-chain fatty alcohol amine called sphingosine which exists in cellular membranes, cytoplasm, nucleus, interstitial fluid, blood and lymphatic circulation. SLs act as essential constituents of membranes of eukaryotic cells, so the seesaw of SLs will lead to structural alteration of membranes instigating cellular functional change. SLs also act as crucial signaling molecules taking effect intracellularly or extracellularly which regulates activity of downstream molecules determining cellular adaptation to numerous stimulus. This review aims to highlight the contribution of SLs to physiological and pathophysiological remodeling of vasculature. We will first provide a short overview on metabolism, trafficking and compartmentalization of SLs. Then the regulation of SLs on reactive oxygen species (ROS) formation, vascular tone modulation, endothelial barrier integrity, apoptosis and autophagy are summarized. Finally, we will discuss how the SLs are modulated contributing to vascular development, angiogenesis and vascular remodeling in pathological situations as hypertension, atherosclerosis, and aging. The compellingly regulative actions of SLs bring about copious therapeutic targets for potential pharmacological intervention on the diseases involving vascular maladaptation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|