Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease?
| Autor: | Dario Arnaldi, Marie Vidailhet, Alice Latimier, Fabrizio De Carli, Isabelle Arnulf, Smaranda Leu-Semenescu |
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| Přispěvatelé: | Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] (DINOGMI), Universita degli studi di Genova, Service des Pathologies du sommeil [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Institute of Bioimaging and Molecular Physiology [Germaneto], National Research Council [Italy] (CNR), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Università degli studi di Genova = University of Genoa (UniGe), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Chin Neurology Polysomnography REM sleep behavior disorder Posture Sleep REM Audiology Non-rapid eye movement sleep 03 medical and health sciences Muscle tone 0302 clinical medicine Muscle Hypertonia medicine Humans Muscle Skeletal Aged Electromyography musculoskeletal neural and ocular physiology Eye movement Parkinson Disease 030206 dentistry Middle Aged synucleinopathy Neurology (clinical) medicine.disease Scientific Investigations medicine.anatomical_structure Hypertonia Wakefulness Female medicine.symptom Psychology 030217 neurology & neurosurgery psychological phenomena and processes [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | JCSM/Journal of Clinical Sleep Medicine JCSM/Journal of Clinical Sleep Medicine, 2016, 12 (06), pp.839-847. ⟨10.5664/jcsm.5882⟩ |
| DOI: | 10.5664/jcsm.5882⟩ |
| Popis: | International audience; Study ObjectivesRigidity is a muscle hypertonia typical of Parkinson disease (PD), whereas rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormally increased muscle tone during REM sleep (REM sleep without atonia) and enacting dream behaviors. Because movements are not bradykinetic during RBD in patients with PD, we investigated whether the background, wake postural rigidity is attenuated during REM sleep without atonia, in absence of movement.MethodsThe amplitude of levator menti (postural muscle) electromyographic activity during relaxed evening wakefulness (considered as reference) and sleep (N2, N3, atonic REM sleep, and quiet REM sleep without atonia) was measured in 20 patients with PD (with and without RBD), 10 patients with idiopathic RBD patients and 10 healthy subjects.ResultsThe chin tone amplitude progressively decreased from wake to N2, N3, and atonic REM sleep in the four groups, but the highest amplitude was observed in PD patients with RBD during atonic REM sleep. Furthermore, chin muscle tone amplitude did not attenuate from wake to REM sleep without atonia in patients with both PD and RBD but dramatically attenuated (by 40% on average) in patients with idiopathic RBD.ConclusionsThe high amplitude of chin muscle tone in PD with RBD (but not in idiopathic RBD) during REM sleep with and without atonia suggests that both PD-related hypertonia and RBD-related enhanced muscle tone coexist during REM sleep, together affecting chin muscle tone. Consequently, some rapid RBD movements likely start against a rigid postural tone. |
| Databáze: | OpenAIRE |
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