Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis
Autor: | Liting Hou, Wenyi Huang, Xianqing Wu, Jingping Qu, Yifeng Chen |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Organic Letters. 24:2699-2704 |
ISSN: | 1523-7052 1523-7060 |
Popis: | Herein, we reported a Ni-catalyzed carbonylation of cyclopropanol with benzyl bromide to afford multisubstituted cyclopentenone under 1 atm of CO. The reaction proceeds through cascade carbonylation of benzyl bromides, followed by generation of nickel homoenolate from cyclopropanols via β-C elimination to afford 1,4-diketones, which undergoes intramolecular Aldol condensation to furnish highly substituted cyclopentenone derivatives in moderate to good yields. The reaction exhibits high functional group tolerance with broad substrate scope. |
Databáze: | OpenAIRE |
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