Prognostic value of increased expression of RBM8A in gastric cancer

Autor: Xinting Lv, Huifei Cheng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Medicine (General)
Physiology
medicine.medical_treatment
Lymph node metastasis
Proto-Oncogene Mas
Biochemistry
0302 clinical medicine
Medicine
Biology (General)
Neoplasm Metastasis
General Pharmacology
Toxicology and Pharmaceutics
Aged
80 and over
Tissue microarray
General Neuroscience
RNA-Binding Proteins
General Medicine
Middle Aged
Prognosis
Immunohistochemistry
Gene Expression Regulation
Neoplastic
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
Research Article
Adult
Proto-oncogene
QH301-705.5
Immunology
Biophysics
Ocean Engineering
03 medical and health sciences
R5-920
Text mining
Stomach Neoplasms
Proto-Oncogene Proteins
Cancer genome
Biomarkers
Tumor
Humans
In patient
RNA
Messenger
Pathological
Aged
Neoplasm Staging
business.industry
Cell Biology
Survival Analysis
RBM8A
030104 developmental biology
Gastric Mucosa
Cancer research
Gastrectomy
business
Gastric cancer
Zdroj: Brazilian Journal of Medical and Biological Research v.53 n.4 2020
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 53, Iss 4 (2020)
Brazilian Journal of Medical and Biological Research, Volume: 53, Issue: 4, Article number: e9290, Published: 09 APR 2020
Popis: This study was designed to investigate the expression of RBM8A protein in patients with gastric cancer (GC) and to explore its correlation with clinical pathological features as well as prognosis. One hundred pairs of gastric carcinoma tissues and adjacent tissues from patients undergoing gastrectomy for GC were included in this study. The protein expression level of RBM8A was determined by immunohistochemistry using tissue microarrays. We also detected the mRNA expression level of RBM8A in 16 pairs of gastric carcinoma tissues and adjacent tissues. Meanwhile, we predicted the potential correlation between RBM8A and tumor stages as well as survival condition in patents with GC based on The Cancer Genome Atlas (TCGA) database. The correlation of RBM8A with the clinical pathological features and prognosis of the 100 patients with GC was also elucidated. The expression level of RBM8A was significantly higher in gastric carcinoma tissues compared to the adjacent tissues. The protein level of RBM8A was correlated with tumor size (P=0.031), depth of invasion (P
Databáze: OpenAIRE
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