Prognostic value of increased expression of RBM8A in gastric cancer
Autor: | Xinting Lv, Huifei Cheng |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Medicine (General) Physiology medicine.medical_treatment Lymph node metastasis Proto-Oncogene Mas Biochemistry 0302 clinical medicine Medicine Biology (General) Neoplasm Metastasis General Pharmacology Toxicology and Pharmaceutics Aged 80 and over Tissue microarray General Neuroscience RNA-Binding Proteins General Medicine Middle Aged Prognosis Immunohistochemistry Gene Expression Regulation Neoplastic Lymphatic Metastasis 030220 oncology & carcinogenesis Female Research Article Adult Proto-oncogene QH301-705.5 Immunology Biophysics Ocean Engineering 03 medical and health sciences R5-920 Text mining Stomach Neoplasms Proto-Oncogene Proteins Cancer genome Biomarkers Tumor Humans In patient RNA Messenger Pathological Aged Neoplasm Staging business.industry Cell Biology Survival Analysis RBM8A 030104 developmental biology Gastric Mucosa Cancer research Gastrectomy business Gastric cancer |
Zdroj: | Brazilian Journal of Medical and Biological Research v.53 n.4 2020 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 53, Iss 4 (2020) Brazilian Journal of Medical and Biological Research, Volume: 53, Issue: 4, Article number: e9290, Published: 09 APR 2020 |
Popis: | This study was designed to investigate the expression of RBM8A protein in patients with gastric cancer (GC) and to explore its correlation with clinical pathological features as well as prognosis. One hundred pairs of gastric carcinoma tissues and adjacent tissues from patients undergoing gastrectomy for GC were included in this study. The protein expression level of RBM8A was determined by immunohistochemistry using tissue microarrays. We also detected the mRNA expression level of RBM8A in 16 pairs of gastric carcinoma tissues and adjacent tissues. Meanwhile, we predicted the potential correlation between RBM8A and tumor stages as well as survival condition in patents with GC based on The Cancer Genome Atlas (TCGA) database. The correlation of RBM8A with the clinical pathological features and prognosis of the 100 patients with GC was also elucidated. The expression level of RBM8A was significantly higher in gastric carcinoma tissues compared to the adjacent tissues. The protein level of RBM8A was correlated with tumor size (P=0.031), depth of invasion (P |
Databáze: | OpenAIRE |
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