Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

Autor: Yoshinari Fukui, Fumiko Ohashi, Masayuki Ikeda, Sonoko Sakuragi, Jiro Moriguchi
Rok vydání: 2010
Předmět:
Zdroj: International Archives of Occupational and Environmental Health. 84:121-129
ISSN: 1432-1246
0340-0131
DOI: 10.1007/s00420-010-0527-1
Popis: The objectives of the present study are to investigate whether cadmium in blood (Cd-B) and cadmium in urine (Cd-U) correlate with each other irrespective of age among general populations and which one of Cd-B or Cd-U correlates more closely with three renal tubular dysfunction markers in urine of α1-microglobulin (α1-MG-U), β2-microglobulin (β2-MG-U) and N-acetyl-β-d-glucosaminidase (NAG-U). Data on two exposure markers (Cd-B and Cd-U) and three effect markers (α1-MG-U, β2-MG-U and NAG-U) were collected for 1,403 adult women in non-polluted areas all over Japan. Possible significance of correlation between the parameters and dependency on age was examined by simple and multiple regression analysis. Both Cd-B and Cd-U increased as a function of age. The two exposure markers correlated significantly with each other, and the Cd-U over Cd-B ratio also increased as a function of age. Although both Cd-B and Cd-U correlated significantly with the three effect markers, the correlation was closer for Cd-U than for Cd-B. Cd-U rather than Cd-B should be recommended as an exposure marker of choice in Cd biological monitoring of general populations. Effects of aging should be taken into account when evaluating study results.
Databáze: OpenAIRE
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