Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
| Autor: | Ludek Raida, Adam Kuba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
DNA damage medicine.medical_treatment Immunology Cellular senescence Graft vs Host Disease chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Review Article Pathogenesis 03 medical and health sciences immune system diseases lcsh:Pathology Medicine Humans Cellular Senescence business.industry Cell Biology medicine.disease 030104 developmental biology Graft-versus-host disease surgical procedures operative business Complication DNA Damage lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2018 (2018) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. |
| Databáze: | OpenAIRE |
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