RNA modifications modulate gene expression during development
Autor: | Michaela Frye, Chuan He, Mikaela Behm, Bryan T. Harada |
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Přispěvatelé: | Frye, Michaela [0000-0002-5636-6840], Harada, Bryan T [0000-0002-9683-782X], Behm, Mikaela [0000-0002-3272-1377], He, Chuan [0000-0003-4319-7424], Apollo - University of Cambridge Repository |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Adenosine Transcription Genetic Cellular differentiation Biology Article 03 medical and health sciences Mice RNA Transfer Transcription (biology) Gene expression Protein biosynthesis Animals Humans Disease RNA Messenger Nucleic acid structure RNA Processing Post-Transcriptional Regulation of gene expression Messenger RNA Multidisciplinary RNA Gene Expression Regulation Developmental Cell Differentiation Methyltransferases 3. Good health Cell biology 030104 developmental biology RNA Ribosomal |
Popis: | RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N 6 -methyladenosine (m 6 A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development. |
Databáze: | OpenAIRE |
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