Effects of Thrombophilia and Antithrombotic Therapy on Embryonic Chromosomal Aberration Rates in Patients with Recurrent Pregnancy Loss
| Autor: | Yoshimitsu Kuwabara, Mirei Yonezawa, Sayuri Kasano, Toshiyuki Takeshita, Ryoko Yokote, Ryuhei Kurashina, Tomoko Ichikawa, Ikuno Kawabata, Nozomi Ouchi |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Abortion Habitual medicine.medical_specialty Thrombophilia Miscarriage 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Pregnancy Uterine malformation Antithrombotic medicine Humans Chromosome Aberrations Aspirin business.industry Obstetrics Incidence (epidemiology) General Medicine medicine.disease Products of conception Urogenital Abnormalities 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Journal of Nippon Medical School. 89:40-46 |
| ISSN: | 1347-3409 1345-4676 |
| DOI: | 10.1272/jnms.jnms.2022_89-103 |
| Popis: | Background Miscarriage occurs in 10-15% of pregnancies and recurrent pregnancy loss (RPL) occurs in 1% of couples hoping for a child. Various risk factors, such as thrombophilia, uterine malformation, and embryonic chromosomal aberration cause RPL. We hypothesized that antithrombotic therapy for RPL patients with thrombophilia would reduce miscarriage due to thrombophilia, which would reduce the total miscarriages and result in a relative increase in miscarriage due to embryonic chromosomal aberrations. In this study, we investigated the incidence of chromosomal aberrations in products of conception in RPL patients with and without antithrombotic therapy. Methods We performed a single-center, retrospective review of cases diagnosed as miscarriage with embryo chromosome analysis between July 1, 2000, and May 31, 2019. Rates of chromosomal aberration were compared between RPL patients with and without thrombophilia or antithrombotic therapy. Results One hundred and-ninety RPL cases were analyzed. The average age was 37.4 ± 4.3 years, and the average number of previous pregnancy losses was 2.2 ± 1.1. The overall chromosomal aberration rate was 67.4% (128/190). There was no difference in the chromosomal aberration rate between the factors for RPL, with or without thrombophilia, and antithrombotic therapy. Only advancing maternal age had significant correlation to increased embryo chromosomal aberration rates. Conclusions With or without antithrombotic therapy, miscarriage was caused by embryonic chromosome abnormalities at a certain rate. Antithrombotic therapy in RPL patients with thrombophilia may reduce abortions due to thrombophilia, which may also normalize the rate of embryonic chromosome aberrations in the subsequent miscarriages. |
| Databáze: | OpenAIRE |
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