4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction

Autor:	Gregory D. Goggins, Valentin K. Gribkoff, Kim Flint, Piyasena Hewawasam, Min Ding, Steven I. Dworetzky, Nicholas J. Lodge, Wenhong Fan, Robert A. Myers, John E. Starrett, Christopher G. Boissard, Deborah A. Cook
Rok vydání:	2003
Předmět:	Male Muscle Relaxation Xenopus Blood Pressure Pharmacology In Vitro Techniques Quinolones chemistry.chemical_compound Potassium Channels Calcium-Activated Structure-Activity Relationship Erectile Dysfunction In vivo Drug Discovery medicine Pressure Animals Large-Conductance Calcium-Activated Potassium Channels Lagomorpha biology Chemistry Aryl Penile Erection Muscle Smooth medicine.disease biology.organism_classification In vitro Antispasmodic Agent Electric Stimulation Rats Inbred F344 Rats Electrophysiology Erectile dysfunction Biochemistry Molecular Medicine Rabbits Penis
Zdroj:	Journal of medicinal chemistry. 46(14)
ISSN:	0022-2623
Popis:	Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. From this study, a potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f20d2a78d18c3b974baf83216da848 https://pubmed.ncbi.nlm.nih.gov/12825925 Zobrazit plný text záznamu