Persistence of Gamma-H2AX Foci in Bronchial Cells Correlates with Susceptibility to Radiation Associated Lung Cancer in Mice
| Autor: | Peter Demant, Takamitsu A. Kato, Donasian O. Ochola, Christina M. Fallgren, Sylvain V. Costes, Thomas J. Keefe, Michael M. Weil, Joel S. Bedford, Rabab Sharif |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Lung Neoplasms Neoplasms Radiation-Induced Biophysics Bronchi Biology Persistence (computer science) Histones 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Radiology Nuclear Medicine and imaging DNA Breaks Double-Stranded Genetic Predisposition to Disease Lung cancer Mice Inbred BALB C Radiation Strain (chemistry) Epithelial Cells medicine.disease 030104 developmental biology Gamma h2ax 030220 oncology & carcinogenesis Dna breaks Radiation associated Cancer research Female Double stranded |
| Zdroj: | Radiation research. 191(1) |
| ISSN: | 1938-5404 |
| Popis: | The risk of developing radiation-induced lung cancer differs between different strains of mice, but the underlying cause of the strain differences is unknown. Strains of mice also differ in how quickly they repair radiation-induced DNA double-strand breaks (DSBs). We assayed mouse strains from the CcS/Dem recombinant congenic strain set for their efficacy in repairing DNA DSBs during protracted irradiation. We measured unrepaired γ-H2AX radiation-induced foci (RIF), which persisted after chronic 24-h gamma irradiation, as a surrogate marker for repair efficiency in bronchial epithelial cells for 17 of the CcS/Dem strains and the BALB/c founder strain. We observed a very strong correlation (R |
| Databáze: | OpenAIRE |
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